We study

Human malaria parasites: Plasmodium falciparum, Plasmodium vivax

Rodent malaria parasites: Plasmodium yoelii, Plasmodium berghei

Publications

View most recent publications on PubMed

  1. Dietrich MH, Chmielewski J, Chan LJ, Tan LL, Adair A, Lyons FMT, Gabriela M, Lopaticki S, Dite TA, Dagley LF, Pazzagli L, Gupta P, Kamil M, Vaughan AM, Rojrung R, Abraham A, Mazhari R, Longley RJ, Zeglinski K, Gouil Q, Mueller I, Fabb SA, Shandre-Mugan R, Pouton CW, Glukhova A, Shakeel S, Tham WH. Cryo-EM structure of endogenous Plasmodium falciparum Pfs230 and Pfs48/45 fertilization complex. Science. 2025 Sep 11;389(6765):eady0241. doi: 10.1126/science.ady0241. Epub 2025 Sep 11. PubMed PMID: 40743371.

  2. Sievert MAC, Qahash T, Singh PP, Shoue DA, Checkley LA, Brenneman KV, Cassady Z, Kumar S, Li X, Nosten FH, Anderson TJC, Vaughan AM, Romero-Severson J, Ferdig MT. Measuring growth, resistance, and recovery after artemisinin treatment of Plasmodium falciparum in a single semi-high-throughput assay. Malar J. 2025 Aug 14;24(1):263. doi: 10.1186/s12936-025-05481-9. PubMed PMID: 40814090; PubMed Central PMCID: PMC12355871.

  3. Aniweh Y, Dziekan J, Jore MM, Kho S, Mancio-Silva L, Merrick CJ, Nahrendorf W, Ralph SA, Vaughan AM, Verhoef JMJ. BioMalPar at 21 - a coming of age for malaria research and interventions. Trends Parasitol. 2025 Sep;41(9):703-708. doi: 10.1016/j.pt.2025.07.011. Epub 2025 Aug 6. PubMed PMID: 40774865.

  4. Li X, Jutzeler KS, Abatiyow BA, Rezakhani N, Haile MT, Leeb AS, Patel H, Kappe SHI, Nosten F, Cheeseman IH, Ferdig MT, Anderson TJC, Vaughan AM, Kumar S. Advantages of outcrossing in Plasmodium falciparum: insights from genetic crosses using fluorescent labelled parasites. bioRxiv. 2025 Jul 31;. doi: 10.1101/2025.07.18.665596. PubMed PMID: 40766536; PubMed Central PMCID: PMC12324223.

  5. Gupta P, Rezakhani N, Pazzagli L, Patel H, Zanghi G, Kamil M, Watson A, Vigdorovich V, Camargo N, Knutson E, Sather DN, Vaughan AM, Swearingen KE. Glycosylation of Plasmodium falciparum TRAP is essential for infection of mosquito salivary glands. bioRxiv. 2025 Jun 26;. doi: 10.1101/2025.06.26.658380. PubMed PMID: 40667256; PubMed Central PMCID: PMC12262273.

  6. Lam M, Probst A, Torres L, Lantigua AA, Fishbaugher ME, Kumar JR, Saldivia M, Torres A, Hegde S, Aleshnick M, Jennison C, Roberson SGH, Joyner CJ, Vaughan AM, Wilder BK, Manneville C, Flannery EL, Marcellin D, Nyfeler B, Thiel Z, Mikolajczak SA, Harupa A, Mitchell G. HaloPROTAC3 does not trigger the degradation of the halotagged parasitophorous vacuole membrane protein UIS4 during Plasmodium liver stage development. Sci Rep. 2025 May 26;15(1):18323. doi: 10.1038/s41598-025-98257-9. PubMed PMID: 40419780; PubMed Central PMCID: PMC12106710.

  7. Aleshnick M, Hegde S, Jennison C, Mikolajczak SA, Vaughan AM, Haumpy D, Martinson T, Straimer J, Wilder BK. Generation of a Transgenic Plasmodium cynomolgi Parasite Expressing Plasmodium vivax Circumsporozoite Protein for Testing P. vivax CSP-Based Malaria Vaccines in Non-Human Primates. Vaccines (Basel). 2025 May 17;13(5). doi: 10.3390/vaccines13050536. PubMed PMID: 40432145; PubMed Central PMCID: PMC12115629.

  8. Wong W, Wang L, Schaffner SF, Li X, Cheeseman I, Anderson TJC, Vaughan A, Ferdig M, Volkman SK, Hartl DL, Wirth DF. MalKinID: A classification model for identifying malaria parasite genealogical relationships using identity-by-descent. Genetics. 2025 Feb 5;229(2). doi: 10.1093/genetics/iyae197. PubMed PMID: 39579070; PubMed Central PMCID: PMC11796457.

  9. Zanghí G, Patel H, Smith JL, Camargo N, Bae Y, Hesping E, Boddey JA, Venugopal K, Marti M, Flannery EL, Chuenchob V, Fishbaugher ME, Mikolajczak SA, Roobsoong W, Sattabongkot J, Gupta P, Pazzagli L, Rezakhani N, Betz W, Hayes K, Goswami D, Vaughan AM, Kappe SHI. Genome-wide gene expression profiles throughout human malaria parasite liver stage development in humanized mice. Nat Microbiol. 2025 Feb;10(2):569-584. doi: 10.1038/s41564-024-01905-5. Epub 2025 Jan 31. PubMed PMID: 39891010; PubMed Central PMCID: PMC11790487.

  10. Dacon C, Moskovitz R, Swearingen K, Da Silva Pereira L, Flores-Garcia Y, Aleshnick M, Kanatani S, Flynn B, Molina-Cruz A, Wollenberg K, Traver M, Kirtley P, Purser L, Dillon M, Bonilla B, Franco A, Petros S, Kritzberg J, Tucker C, Paez GG, Gupta P, Shears MJ, Pazzi J, Edgar JM, Teng AA, Belmonte A, Oda K, Doumbo S, Krymskaya L, Skinner J, Li S, Ghosal S, Kayentao K, Ongoiba A, Vaughan A, Campo JJ, Traore B, Barillas-Mury C, Wijayalath W, Idris A, Crompton PD, Sinnis P, Wilder BK, Zavala F, Seder RA, Wilson IA, Tan J. Protective antibodies target cryptic epitope unmasked by cleavage of malaria sporozoite protein. Science. 2025 Jan 3;387(6729):eadr0510. doi: 10.1126/science.adr0510. Epub 2025 Jan 3. PubMed PMID: 39745947; PubMed Central PMCID: PMC11804177.

  11. Winnicki AC, Dietrich MH, Yeoh LM, Carias LL, Roobsoong W, Drago CL, Malachin AN, Redinger KR, Feufack-Donfack LB, Baldor L, Jung NC, McLaine OS, Skomorovska-Prokvolit Y, Orban A, Opi DH, Kirtley P, Nielson K, Aleshnick M, Zanghi G, Rezakhani N, Vaughan AM, Wilder BK, Sattabongkot J, Tham WH, Popovici J, Beeson JG, Bosch J, King CL. Potent AMA1-specific human monoclonal antibody against Plasmodium vivax Pre-erythrocytic and Blood Stages. Nat Commun. 2024 Dec 4;15(1):10556. doi: 10.1038/s41467-024-53848-4. PubMed PMID: 39632799; PubMed Central PMCID: PMC11618605.

  12. Sievert MAC, Singh PP, Shoue DA, Checkley LA, Brenneman KM, Qahash T, Cassady Z, Kumar S, Li X, Nosten FH, Anderson TJC, Vaughan AM, Romero-Severson J, Ferdig MT. Measuring Growth, Resistance, and Recovery after Artemisinin Treatment of Plasmodium falciparum in a single semi-high-throughput Assay. bioRxiv. 2024 Nov 11;. doi: 10.1101/2024.11.11.623064. PubMed PMID: 39605531; PubMed Central PMCID: PMC11601240.

  13. Wong W, Wang L, Schaffner SS, Li X, Cheeseman I, Anderson TJC, Vaughan A, Ferdig M, Volkman SK, Hartl DL, Wirth DF. MalKinID: A Likelihood-Based Model for Identifying Malaria Parasite Genealogical Relationships Using Identity-by-Descent. bioRxiv. 2024 Jul 16;. doi: 10.1101/2024.07.12.603328. PubMed PMID: 39071294; PubMed Central PMCID: PMC11275886.

  14. Kane J, Li X, Kumar S, Button-Simons KA, Vendrely Brenneman KM, Dahlhoff H, Sievert MAC, Checkley LA, Shoue DA, Singh PP, Abatiyow BA, Haile MT, Nair S, Reyes A, Tripura R, Peto TJ, Lek D, Mukherjee A, Kappe SHI, Dhorda M, Nkhoma SC, Cheeseman IH, Vaughan AM, Anderson TJC, Ferdig MT. A Plasmodium falciparum genetic cross reveals the contributions of pfcrt and plasmepsin II/III to piperaquine drug resistance. mBio. 2024 Jul 17;15(7):e0080524. doi: 10.1128/mbio.00805-24. Epub 2024 Jun 24. PubMed PMID: 38912775; PubMed Central PMCID: PMC11253641.

  15. Goswami D, Patel H, Betz W, Armstrong J, Camargo N, Patil A, Chakravarty S, Murphy SC, Sim BKL, Vaughan AM, Hoffman SL, Kappe SH. A replication competent Plasmodium falciparum parasite completely attenuated by dual gene deletion. EMBO Mol Med. 2024 Apr;16(4):723-754. doi: 10.1038/s44321-024-00057-7. Epub 2024 Mar 21. PubMed PMID: 38514791; PubMed Central PMCID: PMC11018819.

  16. Jennison C, Armstrong JM, Dankwa DA, Hertoghs N, Kumar S, Abatiyow BA, Naung M, Minkah NK, Swearingen KE, Moritz R, Barry AE, Kappe SHI, Vaughan AM. Plasmodium GPI-anchored micronemal antigen is essential for parasite transmission through the mosquito host. Mol Microbiol. 2024 Mar;121(3):394-412. doi: 10.1111/mmi.15078. Epub 2023 Jun 14. PubMed PMID: 37314965; PubMed Central PMCID: PMC11076100.

  17. Amambua-Ngwa A, Button-Simons KA, Li X, Kumar S, Brenneman KV, Ferrari M, Checkley LA, Haile MT, Shoue DA, McDew-White M, Tindall SM, Reyes A, Delgado E, Dalhoff H, Larbalestier JK, Amato R, Pearson RD, Taylor AB, Nosten FH, D'Alessandro U, Kwiatkowski D, Cheeseman IH, Kappe SHI, Avery SV, Conway DJ, Vaughan AM, Ferdig MT, Anderson TJC. Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1. Nat Microbiol. 2023 Jul;8(7):1213-1226. doi: 10.1038/s41564-023-01377-z. Epub 2023 May 11. PubMed PMID: 37169919; PubMed Central PMCID: PMC10322710.

  18. Zanghi G, Patel H, Camargo N, Smith JL, Bae Y, Flannery EL, Chuenchob V, Fishbaugher ME, Mikolajczak SA, Roobsoong W, Sattabongkot J, Hayes K, Vaughan AM, Kappe SHI. Global gene expression of human malaria parasite liver stages throughout intrahepatocytic development. bioRxiv. 2023 Jan 5;. doi: 10.1101/2023.01.05.522945. PubMed PMID: 36711670; PubMed Central PMCID: PMC9881933.

  19. Richie TL, Church LWP, Murshedkar T, Billingsley PF, James ER, Chen MC, Abebe Y, K C N, Chakravarty S, Dolberg D, Healy SA, Diawara H, Sissoko MS, Sagara I, Cook DM, Epstein JE, Mordmüller B, Kapulu M, Kreidenweiss A, Franke-Fayard B, Agnandji ST, López Mikue MA, McCall MBB, Steinhardt L, Oneko M, Olotu A, Vaughan AM, Kublin JG, Murphy SC, Jongo S, Tanner M, Sirima SB, Laurens MB, Daubenberger C, Silva JC, Lyke KE, Janse CJ, Roestenberg M, Sauerwein RW, Abdulla S, Dicko A, Kappe SHI, Sim BKL, Duffy PE, Kremsner PG, Hoffman SL. Sporozoite immunization: innovative translational science to support the fight against malaria. Expert Rev Vaccines. 2023 Jan-Dec;22(1):964-1007. doi: 10.1080/14760584.2023.2245890. Epub 2023 Aug 11. Review. PubMed PMID: 37571809; PubMed Central PMCID: PMC10949369.

  20. Oduselu GO, Afolabi R, Ademuwagun I, Vaughan A, Adebiyi E. Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of Plasmodium falciparum 5-aminolevulinate synthase inhibitors. Front Med (Lausanne). 2022;9:1022429. doi: 10.3389/fmed.2022.1022429. eCollection 2022. PubMed PMID: 36714108; PubMed Central PMCID: PMC9877529.

  21. Kumar S, Valansi C, Haile MT, Li X, Flyak K, Dwivedy A, Abatiyow BA, Leeb AS, Kennedy SY, Camargo NM, Vaughan AM, Brukman NG, Podbilewicz B, Kappe SHI. Malaria parasites utilize two essential plasma membrane fusogens for gamete fertilization. Cell Mol Life Sci. 2022 Oct 14;79(11):549. doi: 10.1007/s00018-022-04583-w. PubMed PMID: 36241929; PubMed Central PMCID: PMC9568910.

  22. Kumar S, Baranwal VK, Leeb AS, Haile MT, Oualim KMZ, Hertoghs N, Vaughan AM, Kappe SHI. PfSRPK1 Regulates Asexual Blood Stage Schizogony and Is Essential for Male Gamete Formation. Microbiol Spectr. 2022 Oct 26;10(5):e0214122. doi: 10.1128/spectrum.02141-22. Epub 2022 Sep 12. PubMed PMID: 36094218; PubMed Central PMCID: PMC9602455.

  23. Murphy SC, Vaughan AM, Kublin JG, Fishbauger M, Seilie AM, Cruz KP, Mankowski T, Firat M, Magee S, Betz W, Kain H, Camargo N, Haile MT, Armstrong J, Fritzen E, Hertoghs N, Kumar S, Sather DN, Pinder LF, Deye GA, Galbiati S, Geber C, Butts J, Jackson LA, Kappe SHI. A genetically engineered Plasmodium falciparum parasite vaccine provides protection from controlled human malaria infection. Sci Transl Med. 2022 Aug 24;14(659):eabn9709. doi: 10.1126/scitranslmed.abn9709. Epub 2022 Aug 24. PubMed PMID: 36001680; PubMed Central PMCID: PMC10423335.

  24. Kumar S, Baranwal VK, Haile MT, Oualim KMZ, Abatiyow BA, Kennedy SY, Vaughan AM, Kappe SHI. PfARID Regulates P. falciparum Malaria Parasite Male Gametogenesis and Female Fertility and Is Critical for Parasite Transmission to the Mosquito Vector. mBio. 2022 Jun 28;13(3):e0057822. doi: 10.1128/mbio.00578-22. Epub 2022 May 31. PubMed PMID: 35638735; PubMed Central PMCID: PMC9239086.

  25. Kumar S, Li X, McDew-White M, Reyes A, Delgado E, Sayeed A, Haile MT, Abatiyow BA, Kennedy SY, Camargo N, Checkley LA, Brenneman KV, Button-Simons KA, Duraisingh MT, Cheeseman IH, Kappe SHI, Nosten F, Ferdig MT, Vaughan AM, Anderson TJC. A Malaria Parasite Cross Reveals Genetic Determinants of Plasmodium falciparum Growth in Different Culture Media. Front Cell Infect Microbiol. 2022;12:878496. doi: 10.3389/fcimb.2022.878496. eCollection 2022. PubMed PMID: 35711667; PubMed Central PMCID: PMC9197316.

  26. Goswami D, Kumar S, Betz W, Armstrong JM, Haile MT, Camargo N, Parthiban C, Seilie AM, Murphy SC, Vaughan AM, Kappe SHI. A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony. iScience. 2022 May 20;25(5):104224. doi: 10.1016/j.isci.2022.104224. eCollection 2022 May 20. PubMed PMID: 35521513; PubMed Central PMCID: PMC9061783.

  27. Kumar S, Abatiyow BA, Haile MT, Oualim KMZ, Leeb AS, Vaughan AM, Kappe SHI. A Putative Plasmodium RNA-Binding Protein Plays a Critical Role in Female Gamete Fertility and Parasite Transmission to the Mosquito Vector. Front Cell Dev Biol. 2022;10:825247. doi: 10.3389/fcell.2022.825247. eCollection 2022. PubMed PMID: 35465336; PubMed Central PMCID: PMC9022223.

  28. Brenneman KV, Li X, Kumar S, Delgado E, Checkley LA, Shoue DA, Reyes A, Abatiyow BA, Haile MT, Tripura R, Peto T, Lek D, Button-Simons KA, Kappe SHI, Dhorda M, Nosten F, Nkhoma SC, Cheeseman IH, Vaughan AM, Ferdig MT, Anderson TJC. Optimizing bulk segregant analysis of drug resistance using Plasmodium falciparum genetic crosses conducted in humanized mice. iScience. 2022 Apr 15;25(4):104095. doi: 10.1016/j.isci.2022.104095. eCollection 2022 Apr 15. PubMed PMID: 35372813; PubMed Central PMCID: PMC8971943.

  29. Kumar S, Leeb AS, Vaughan AM, Kappe SHI. Plasmodium falciparum Cysteine Rich Secretory Protein uniquely localizes to one end of male gametes. Mol Biochem Parasitol. 2022 Mar;248:111447. doi: 10.1016/j.molbiopara.2022.111447. Epub 2022 Jan 5. PubMed PMID: 34998927; PubMed Central PMCID: PMC8904303.

  30. Kumar S, Haile MT, Hoopmann MR, Tran LT, Michaels SA, Morrone SR, Ojo KK, Reynolds LM, Kusebauch U, Vaughan AM, Moritz RL, Kappe SHI, Swearingen KE. Plasmodium falciparum Calcium-Dependent Protein Kinase 4 is Critical for Male Gametogenesis and Transmission to the Mosquito Vector. mBio. 2021 Dec 21;12(6):e0257521. doi: 10.1128/mBio.02575-21. Epub 2021 Nov 2. PubMed PMID: 34724830; PubMed Central PMCID: PMC8561384.

  31. Kublin JG, Murphy SC, Maenza J, Seilie AM, Jain JP, Berger D, Spera D, Zhao R, Soon RL, Czartoski JL, Potochnic MA, Duke E, Chang M, Vaughan A, Kappe SHI, Leong FJ, Pertel P, Prince WT. Safety, Pharmacokinetics, and Causal Prophylactic Efficacy of KAF156 in a Plasmodium falciparum Human Infection Study. Clin Infect Dis. 2021 Oct 5;73(7):e2407-e2414. doi: 10.1093/cid/ciaa952. PubMed PMID: 32644127; PubMed Central PMCID: PMC8678739.

  32. Zanghi G, Vaughan AM. Plasmodium vivax pre-erythrocytic stages and the latent hypnozoite. Parasitol Int. 2021 Dec;85:102447. doi: 10.1016/j.parint.2021.102447. Epub 2021 Aug 30. Review. PubMed PMID: 34474178.

  33. Schäfer C, Zanghi G, Vaughan AM, Kappe SHI. Plasmodium vivax Latent Liver Stage Infection and Relapse: Biological Insights and New Experimental Tools. Annu Rev Microbiol. 2021 Oct 8;75:87-106. doi: 10.1146/annurev-micro-032421-061155. Epub 2021 Jul 1. Review. PubMed PMID: 34196569.

  34. Button-Simons KA, Kumar S, Carmago N, Haile MT, Jett C, Checkley LA, Kennedy SY, Pinapati RS, Shoue DA, McDew-White M, Li X, Nosten FH, Kappe SH, Anderson TJC, Romero-Severson J, Ferdig MT, Emrich SJ, Vaughan AM, Cheeseman IH. The power and promise of genetic mapping from Plasmodium falciparum crosses utilizing human liver-chimeric mice. Commun Biol. 2021 Jun 14;4(1):734. doi: 10.1038/s42003-021-02210-1. PubMed PMID: 34127785; PubMed Central PMCID: PMC8203791.

  35. Vaughan A. Motile mosquito stage malaria parasites: ready for their close-up. EMBO Mol Med. 2021 Apr 9;13(4):e13975. doi: 10.15252/emmm.202113975. Epub 2021 Mar 31. PubMed PMID: 33787077; PubMed Central PMCID: PMC8033511.

  36. Vendrely KM, Kumar S, Li X, Vaughan AM. Humanized Mice and the Rebirth of Malaria Genetic Crosses. Trends Parasitol. 2020 Oct;36(10):850-863. doi: 10.1016/j.pt.2020.07.009. Epub 2020 Sep 2. Review. PubMed PMID: 32891493; PubMed Central PMCID: PMC7530086.

  37. Goswami D, Betz W, Locham NK, Parthiban C, Brager C, Schäfer C, Camargo N, Nguyen T, Kennedy SY, Murphy SC, Vaughan AM, Kappe SH. A replication-competent late liver stage-attenuated human malaria parasite. JCI Insight. 2020 Jul 9;5(13). doi: 10.1172/jci.insight.135589. PubMed PMID: 32484795; PubMed Central PMCID: PMC7406309.

  38. Zhou Y, Grieser AM, Do J, Itsara LS, Vaughan AM, Ghosh AK. Purification and production of Plasmodium falciparum zygotes from in vitro culture using magnetic column and Percoll density gradient. Malar J. 2020 May 25;19(1):192. doi: 10.1186/s12936-020-03237-1. PubMed PMID: 32450861; PubMed Central PMCID: PMC7249376.

  39. Li X, Kumar S, McDew-White M, Haile M, Cheeseman IH, Emrich S, Button-Simons K, Nosten F, Kappe SHI, Ferdig MT, Anderson TJC, Vaughan AM. Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle. PLoS Genet. 2019 Oct;15(10):e1008453. doi: 10.1371/journal.pgen.1008453. eCollection 2019 Oct. PubMed PMID: 31609965; PubMed Central PMCID: PMC6821138.

  40. Minkah NK, Wilder BK, Sheikh AA, Martinson T, Wegmair L, Vaughan AM, Kappe SHI. Innate immunity limits protective adaptive immune responses against pre-erythrocytic malaria parasites. Nat Commun. 2019 Sep 2;10(1):3950. doi: 10.1038/s41467-019-11819-0. PubMed PMID: 31477704; PubMed Central PMCID: PMC6718385.

  41. Tirrell AR, Vendrely KM, Checkley LA, Davis SZ, McDew-White M, Cheeseman IH, Vaughan AM, Nosten FH, Anderson TJC, Ferdig MT. Pairwise growth competitions identify relative fitness relationships among artemisinin resistant Plasmodium falciparum field isolates. Malar J. 2019 Aug 28;18(1):295. doi: 10.1186/s12936-019-2934-4. PubMed PMID: 31462253; PubMed Central PMCID: PMC6714446.

  42. Flannery EL, Markus MB, Vaughan AM. Plasmodium vivax. Trends Parasitol. 2019 Jul;35(7):583-584. doi: 10.1016/j.pt.2019.04.005. Epub 2019 Jun 5. Review. PubMed PMID: 31176582.

  43. Seilie AM, Chang M, Hanron AE, Billman ZP, Stone BC, Zhou K, Olsen TM, Daza G, Ortega J, Cruz KR, Smith N, Healy SA, Neal J, Wallis CK, Shelton L, Mankowski TV, Wong-Madden S, Mikolajczak SA, Vaughan AM, Kappe SHI, Fishbaugher M, Betz W, Kennedy M, Hume JCC, Talley AK, Hoffman SL, Chakravarty S, Sim BKL, Richie TL, Wald A, Plowe CV, Lyke KE, Adams M, Fahle GA, Cowan EP, Duffy PE, Kublin JG, Murphy SC. Beyond Blood Smears: Qualification of Plasmodium 18S rRNA as a Biomarker for Controlled Human Malaria Infections. Am J Trop Med Hyg. 2019 Jun;100(6):1466-1476. doi: 10.4269/ajtmh.19-0094. PubMed PMID: 31017084; PubMed Central PMCID: PMC6553913.

  44. Gupta DK, Dembele L, Voorberg-van der Wel A, Roma G, Yip A, Chuenchob V, Kangwanrangsan N, Ishino T, Vaughan AM, Kappe SH, Flannery EL, Sattabongkot J, Mikolajczak S, Bifani P, Kocken CH, Diagana TT. The Plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development. Elife. 2019 May 16;8. doi: 10.7554/eLife.43362. PubMed PMID: 31094679; PubMed Central PMCID: PMC6542585.

  45. Itsara LS, Zhou Y, Do J, Grieser AM, Vaughan AM, Ghosh AK. The Development of Whole Sporozoite Vaccines for Plasmodium falciparum Malaria. Front Immunol. 2018;9:2748. doi: 10.3389/fimmu.2018.02748. eCollection 2018. Review. PubMed PMID: 30619241; PubMed Central PMCID: PMC6297750.

  46. Arredondo SA, Swearingen KE, Martinson T, Steel R, Dankwa DA, Harupa A, Camargo N, Betz W, Vigdorovich V, Oliver BG, Kangwanrangsan N, Ishino T, Sather N, Mikolajczak S, Vaughan AM, Torii M, Moritz RL, Kappe SHI. The Micronemal Plasmodium Proteins P36 and P52 Act in Concert to Establish the Replication-Permissive Compartment Within Infected Hepatocytes. Front Cell Infect Microbiol. 2018;8:413. doi: 10.3389/fcimb.2018.00413. eCollection 2018. PubMed PMID: 30547015; PubMed Central PMCID: PMC6280682.

  47. Vaughan AM, Sack BK, Dankwa D, Minkah N, Nguyen T, Cardamone H, Kappe SHI. A Plasmodium Parasite with Complete Late Liver Stage Arrest Protects against Preerythrocytic and Erythrocytic Stage Infection in Mice. Infect Immun. 2018 May;86(5). doi: 10.1128/IAI.00088-18. Print 2018 May. PubMed PMID: 29440367; PubMed Central PMCID: PMC5913857.

  48. Itsara LS, Zhou Y, Do J, Dungel S, Fishbaugher ME, Betz WW, Nguyen T, Navarro MJ, Flannery EL, Vaughan AM, Kappe SHI, Ghosh AK. PfCap380 as a marker for Plasmodium falciparum oocyst development in vivo and in vitro. Malar J. 2018 Apr 2;17(1):135. doi: 10.1186/s12936-018-2277-6. PubMed PMID: 29609625; PubMed Central PMCID: PMC5880026.

  49. Steel RWJ, Pei Y, Camargo N, Kaushansky A, Dankwa DA, Martinson T, Nguyen T, Betz W, Cardamone H, Vigdorovich V, Dambrauskas N, Carbonetti S, Vaughan AM, Sather DN, Kappe SHI. Plasmodium yoelii S4/CelTOS is important for sporozoite gliding motility and cell traversal. Cell Microbiol. 2018 Apr;20(4). doi: 10.1111/cmi.12817. Epub 2018 Jan 12. PubMed PMID: 29253313.

  50. Zander RA, Vijay R, Pack AD, Guthmiller JJ, Graham AC, Lindner SE, Vaughan AM, Kappe SHI, Butler NS. Th1-like Plasmodium-Specific Memory CD4(+) T Cells Support Humoral Immunity. Cell Rep. 2017 Nov 14;21(7):1839-1852. doi: 10.1016/j.celrep.2017.10.077. PubMed PMID: 29141217; PubMed Central PMCID: PMC5693336.

  51. Sack BK, Mikolajczak SA, Fishbaugher M, Vaughan AM, Flannery EL, Nguyen T, Betz W, Jane Navarro M, Foquet L, Steel RWJ, Billman ZP, Murphy SC, Hoffman SL, Chakravarty S, Sim BKL, Behet M, Reuling IJ, Walk J, Scholzen A, Sauerwein RW, Ishizuka AS, Flynn B, Seder RA, Kappe SHI. Humoral protection against mosquito bite-transmitted Plasmodium falciparum infection in humanized mice. NPJ Vaccines. 2017;2:27. doi: 10.1038/s41541-017-0028-2. eCollection 2017. PubMed PMID: 29263882; PubMed Central PMCID: PMC5634440.

  52. Swearingen KE, Lindner SE, Flannery EL, Vaughan AM, Morrison RD, Patrapuvich R, Koepfli C, Muller I, Jex A, Moritz RL, Kappe SHI, Sattabongkot J, Mikolajczak SA. Proteogenomic analysis of the total and surface-exposed proteomes of Plasmodium vivax salivary gland sporozoites. PLoS Negl Trop Dis. 2017 Jul;11(7):e0005791. doi: 10.1371/journal.pntd.0005791. eCollection 2017 Jul. PubMed PMID: 28759593; PubMed Central PMCID: PMC5552340.

  53. Vaughan AM, Kappe SHI. Genetically attenuated malaria parasites as vaccines. Expert Rev Vaccines. 2017 Aug;16(8):765-767. doi: 10.1080/14760584.2017.1341835. Epub 2017 Jun 16. PubMed PMID: 28612631.

  54. Vaughan AM, Kappe SHI. Malaria Parasite Liver Infection and Exoerythrocytic Biology. Cold Spring Harb Perspect Med. 2017 Jun 1;7(6). doi: 10.1101/cshperspect.a025486. Review. PubMed PMID: 28242785; PubMed Central PMCID: PMC5453383.

  55. Kublin JG, Mikolajczak SA, Sack BK, Fishbaugher ME, Seilie A, Shelton L, VonGoedert T, Firat M, Magee S, Fritzen E, Betz W, Kain HS, Dankwa DA, Steel RW, Vaughan AM, Noah Sather D, Murphy SC, Kappe SH. Complete attenuation of genetically engineered Plasmodium falciparum sporozoites in human subjects. Sci Transl Med. 2017 Jan 4;9(371). doi: 10.1126/scitranslmed.aad9099. PubMed PMID: 28053159.

  56. Keitany GJ, Kim KS, Krishnamurty AT, Hondowicz BD, Hahn WO, Dambrauskas N, Sather DN, Vaughan AM, Kappe SHI, Pepper M. Blood Stage Malaria Disrupts Humoral Immunity to the Pre-erythrocytic Stage Circumsporozoite Protein. Cell Rep. 2016 Dec 20;17(12):3193-3205. doi: 10.1016/j.celrep.2016.11.060. PubMed PMID: 28009289; PubMed Central PMCID: PMC5476299.

  57. Dankwa DA, Davis MJ, Kappe SHI, Vaughan AM. A Plasmodium yoelii Mei2-Like RNA Binding Protein Is Essential for Completion of Liver Stage Schizogony. Infect Immun. 2016 May;84(5):1336-1345. doi: 10.1128/IAI.01417-15. Print 2016 May. PubMed PMID: 26883588; PubMed Central PMCID: PMC4862717.

  58. Swearingen KE, Lindner SE, Shi L, Shears MJ, Harupa A, Hopp CS, Vaughan AM, Springer TA, Moritz RL, Kappe SH, Sinnis P. Interrogating the Plasmodium Sporozoite Surface: Identification of Surface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP by Mass Spectrometry-Based Proteomics. PLoS Pathog. 2016 Apr;12(4):e1005606. doi: 10.1371/journal.ppat.1005606. eCollection 2016 Apr. PubMed PMID: 27128092; PubMed Central PMCID: PMC4851412.

  59. Sack BK, Miller JL, Vaughan AM, Kappe SH. Measurement of Antibody-Mediated Reduction of Plasmodium yoelii Liver Burden by Bioluminescent Imaging. Methods Mol Biol. 2015;1325:69-80. doi: 10.1007/978-1-4939-2815-6_6. PubMed PMID: 26450380; PubMed Central PMCID: PMC8441651.

  60. Vaughan AM. Preface. Methods Mol Biol. 2015;1325:v-vi. doi: 10.1007/978-1-4939-2815-6. PubMed PMID: 26730424.

  61. Vaughan AM, Pinapati RS, Cheeseman IH, Camargo N, Fishbaugher M, Checkley LA, Nair S, Hutyra CA, Nosten FH, Anderson TJ, Ferdig MT, Kappe SH. Plasmodium falciparum genetic crosses in a humanized mouse model. Nat Methods. 2015 Jul;12(7):631-3. doi: 10.1038/nmeth.3432. Epub 2015 Jun 1. PubMed PMID: 26030447; PubMed Central PMCID: PMC4547688.

  62. Sack BK, Keitany GJ, Vaughan AM, Miller JL, Wang R, Kappe SH. Mechanisms of stage-transcending protection following immunization of mice with late liver stage-arresting genetically attenuated malaria parasites. PLoS Pathog. 2015 May;11(5):e1004855. doi: 10.1371/journal.ppat.1004855. eCollection 2015 May. PubMed PMID: 25974076; PubMed Central PMCID: PMC4431720.

  63. Mikolajczak SA, Vaughan AM, Kangwanrangsan N, Roobsoong W, Fishbaugher M, Yimamnuaychok N, Rezakhani N, Lakshmanan V, Singh N, Kaushansky A, Camargo N, Baldwin M, Lindner SE, Adams JH, Sattabongkot J, Kappe SH. Plasmodium vivax liver stage development and hypnozoite persistence in human liver-chimeric mice. Cell Host Microbe. 2015 Apr 8;17(4):526-35. doi: 10.1016/j.chom.2015.02.011. Epub 2015 Mar 19. PubMed PMID: 25800544; PubMed Central PMCID: PMC5299596.

  64. Lakshmanan V, Fishbaugher ME, Morrison B, Baldwin M, Macarulay M, Vaughan AM, Mikolajczak SA, Kappe SH. Cyclic GMP balance is critical for malaria parasite transmission from the mosquito to the mammalian host. mBio. 2015 Mar 17;6(2):e02330. doi: 10.1128/mBio.02330-14. PubMed PMID: 25784701; PubMed Central PMCID: PMC4453516.

  65. Murray SA, Mohar I, Miller JL, Brempelis KJ, Vaughan AM, Kappe SH, Crispe IN. CD40 is required for protective immunity against liver stage Plasmodium infection. J Immunol. 2015 Mar 1;194(5):2268-79. doi: 10.4049/jimmunol.1401724. Epub 2015 Feb 2. PubMed PMID: 25646303; PubMed Central PMCID: PMC4340756.

  66. Kaushansky A, Austin LS, Mikolajczak SA, Lo FY, Miller JL, Douglass AN, Arang N, Vaughan AM, Gardner MJ, Kappe SH. Susceptibility to Plasmodium yoelii preerythrocytic infection in BALB/c substrains is determined at the point of hepatocyte invasion. Infect Immun. 2015 Jan;83(1):39-47. doi: 10.1128/IAI.02230-14. Epub 2014 Oct 13. PubMed PMID: 25312960; PubMed Central PMCID: PMC4288894.

  67. Keitany GJ, Sack B, Smithers H, Chen L, Jang IK, Sebastian L, Gupta M, Sather DN, Vignali M, Vaughan AM, Kappe SH, Wang R. Immunization of mice with live-attenuated late liver stage-arresting Plasmodium yoelii parasites generates protective antibody responses to preerythrocytic stages of malaria. Infect Immun. 2014 Dec;82(12):5143-53. doi: 10.1128/IAI.02320-14. Epub 2014 Sep 29. PubMed PMID: 25267837; PubMed Central PMCID: PMC4249261.

  68. Stone WJ, Churcher TS, Graumans W, van Gemert GJ, Vos MW, Lanke KH, van de Vegte-Bolmer MG, Siebelink-Stoter R, Dechering KJ, Vaughan AM, Camargo N, Kappe SH, Sauerwein RW, Bousema T. A scalable assessment of Plasmodium falciparum transmission in the standard membrane-feeding assay, using transgenic parasites expressing green fluorescent protein-luciferase. J Infect Dis. 2014 Nov 1;210(9):1456-63. doi: 10.1093/infdis/jiu271. Epub 2014 May 14. PubMed PMID: 24829466.

  69. Miller JL, Sack BK, Baldwin M, Vaughan AM, Kappe SHI. Interferon-mediated innate immune responses against malaria parasite liver stages. Cell Rep. 2014 Apr 24;7(2):436-447. doi: 10.1016/j.celrep.2014.03.018. Epub 2014 Apr 3. PubMed PMID: 24703850.

  70. Lindner SE, Sartain MJ, Hayes K, Harupa A, Moritz RL, Kappe SH, Vaughan AM. Enzymes involved in plastid-targeted phosphatidic acid synthesis are essential for Plasmodium yoelii liver-stage development. Mol Microbiol. 2014 Feb;91(4):679-93. doi: 10.1111/mmi.12485. Epub 2014 Jan 7. PubMed PMID: 24330260; PubMed Central PMCID: PMC3925071.

  71. Vaughan AM, Kappe SH. Vaccination using radiation- or genetically attenuated live sporozoites. Methods Mol Biol. 2013;923:549-66. doi: 10.1007/978-1-62703-026-7_38. PubMed PMID: 22990804.

  72. Sack BK, Miller JL, Vaughan AM, Douglass A, Kaushansky A, Mikolajczak S, Coppi A, Gonzalez-Aseguinolaza G, Tsuji M, Zavala F, Sinnis P, Kappe SH. Model for in vivo assessment of humoral protection against malaria sporozoite challenge by passive transfer of monoclonal antibodies and immune serum. Infect Immun. 2014 Feb;82(2):808-17. doi: 10.1128/IAI.01249-13. Epub 2013 Dec 9. PubMed PMID: 24478094; PubMed Central PMCID: PMC3911395.

  73. van Schaijk BC, Kumar TR, Vos MW, Richman A, van Gemert GJ, Li T, Eappen AG, Williamson KC, Morahan BJ, Fishbaugher M, Kennedy M, Camargo N, Khan SM, Janse CJ, Sim KL, Hoffman SL, Kappe SH, Sauerwein RW, Fidock DA, Vaughan AM. Type II fatty acid biosynthesis is essential for Plasmodium falciparum sporozoite development in the midgut of Anopheles mosquitoes. Eukaryot Cell. 2014 May;13(5):550-9. doi: 10.1128/EC.00264-13. Epub 2013 Dec 2. PubMed PMID: 24297444; PubMed Central PMCID: PMC4060470.

  74. Cobbold SA, Vaughan AM, Lewis IA, Painter HJ, Camargo N, Perlman DH, Fishbaugher M, Healer J, Cowman AF, Kappe SH, Llinás M. Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum. J Biol Chem. 2013 Dec 20;288(51):36338-50. doi: 10.1074/jbc.M113.503557. Epub 2013 Oct 25. PubMed PMID: 24163372; PubMed Central PMCID: PMC3868748.

  75. Miller JL, Murray S, Vaughan AM, Harupa A, Sack B, Baldwin M, Crispe IN, Kappe SH. Quantitative bioluminescent imaging of pre-erythrocytic malaria parasite infection using luciferase-expressing Plasmodium yoelii. PLoS One. 2013;8(4):e60820. doi: 10.1371/journal.pone.0060820. Print 2013. PubMed PMID: 23593316; PubMed Central PMCID: PMC3623966.

  76. Pei Y, Miller JL, Lindner SE, Vaughan AM, Torii M, Kappe SHI. Plasmodium yoelii inhibitor of cysteine proteases is exported to exomembrane structures and interacts with yoelipain-2 during asexual blood-stage development. Cell Microbiol. 2013 Sep;15(9):1508-1526. doi: 10.1111/cmi.12124. Epub 2013 Mar 14. PubMed PMID: 23421981; PubMed Central PMCID: PMC3907115.

  77. Kaushansky A, Ye AS, Austin LS, Mikolajczak SA, Vaughan AM, Camargo N, Metzger PG, Douglass AN, MacBeath G, Kappe SH. Suppression of host p53 is critical for Plasmodium liver-stage infection. Cell Rep. 2013 Mar 28;3(3):630-7. doi: 10.1016/j.celrep.2013.02.010. Epub 2013 Mar 7. PubMed PMID: 23478020; PubMed Central PMCID: PMC3619000.

  78. Lindner SE, Mikolajczak SA, Vaughan AM, Moon W, Joyce BR, Sullivan WJ Jr, Kappe SH. Perturbations of Plasmodium Puf2 expression and RNA-seq of Puf2-deficient sporozoites reveal a critical role in maintaining RNA homeostasis and parasite transmissibility. Cell Microbiol. 2013 Jul;15(7):1266-83. doi: 10.1111/cmi.12116. Epub 2013 Feb 27. PubMed PMID: 23356439; PubMed Central PMCID: PMC3815636.

  79. Lindner SE, Swearingen KE, Harupa A, Vaughan AM, Sinnis P, Moritz RL, Kappe SH. Total and putative surface proteomics of malaria parasite salivary gland sporozoites. Mol Cell Proteomics. 2013 May;12(5):1127-43. doi: 10.1074/mcp.M112.024505. Epub 2013 Jan 16. PubMed PMID: 23325771; PubMed Central PMCID: PMC3650326.

  80. Kennedy M, Fishbaugher ME, Vaughan AM, Patrapuvich R, Boonhok R, Yimamnuaychok N, Rezakhani N, Metzger P, Ponpuak M, Sattabongkot J, Kappe SH, Hume JC, Lindner SE. A rapid and scalable density gradient purification method for Plasmodium sporozoites. Malar J. 2012 Dec 17;11:421. doi: 10.1186/1475-2875-11-421. PubMed PMID: 23244590; PubMed Central PMCID: PMC3543293.

  81. Vaughan AM, Mikolajczak SA, Camargo N, Lakshmanan V, Kennedy M, Lindner SE, Miller JL, Hume JC, Kappe SH. A transgenic Plasmodium falciparum NF54 strain that expresses GFP-luciferase throughout the parasite life cycle. Mol Biochem Parasitol. 2012 Dec;186(2):143-7. doi: 10.1016/j.molbiopara.2012.10.004. Epub 2012 Oct 27. PubMed PMID: 23107927.

  82. Vaughan AM, Mikolajczak SA, Wilson EM, Grompe M, Kaushansky A, Camargo N, Bial J, Ploss A, Kappe SH. Complete Plasmodium falciparum liver-stage development in liver-chimeric mice. J Clin Invest. 2012 Oct;122(10):3618-28. doi: 10.1172/JCI62684. Epub 2012 Sep 10. PubMed PMID: 22996664; PubMed Central PMCID: PMC3461911.

  83. Vaughan AM, Kappe SH, Ploss A, Mikolajczak SA. Development of humanized mouse models to study human malaria parasite infection. Future Microbiol. 2012 May;7(5):657-65. doi: 10.2217/fmb.12.27. Review. PubMed PMID: 22568719; PubMed Central PMCID: PMC3848604.

  84. Vaughan AM, Kappe SH. Malaria vaccine development: persistent challenges. Curr Opin Immunol. 2012 Jun;24(3):324-31. doi: 10.1016/j.coi.2012.03.009. Epub 2012 Apr 21. Review. PubMed PMID: 22521906.

  85. Butler NS, Vaughan AM, Harty JT, Kappe SH. Whole parasite vaccination approaches for prevention of malaria infection. Trends Immunol. 2012 May;33(5):247-54. doi: 10.1016/j.it.2012.02.001. Epub 2012 Mar 7. Review. PubMed PMID: 22405559.

  86. MacKellar DC, Vaughan AM, Aly AS, DeLeon S, Kappe SH. A systematic analysis of the early transcribed membrane protein family throughout the life cycle of Plasmodium yoelii. Cell Microbiol. 2011 Nov;13(11):1755-67. doi: 10.1111/j.1462-5822.2011.01656.x. Epub 2011 Aug 31. PubMed PMID: 21819513; PubMed Central PMCID: PMC3328200.

  87. Butler NS, Schmidt NW, Vaughan AM, Aly AS, Kappe SH, Harty JT. Superior antimalarial immunity after vaccination with late liver stage-arresting genetically attenuated parasites. Cell Host Microbe. 2011 Jun 16;9(6):451-62. doi: 10.1016/j.chom.2011.05.008. PubMed PMID: 21669394; PubMed Central PMCID: PMC3117254.

  88. de Beer MC, Ji A, Jahangiri A, Vaughan AM, de Beer FC, van der Westhuyzen DR, Webb NR. ATP binding cassette G1-dependent cholesterol efflux during inflammation. J Lipid Res. 2011 Feb;52(2):345-53. doi: 10.1194/jlr.M012328. Epub 2010 Dec 7. PubMed PMID: 21138980; PubMed Central PMCID: PMC3023555.

  89. Kappe SH, Vaughan AM, Boddey JA, Cowman AF. That was then but this is now: malaria research in the time of an eradication agenda. Science. 2010 May 14;328(5980):862-6. doi: 10.1126/science.1184785. Review. PubMed PMID: 20466924.

  90. Mikolajczak SA, Vaughan AM, Soliman JM, Kappe SH. A genetically attenuated parasite vaccine does not require liver stage persistence to elicit sterile protective immunity against sporozoite-induced malaria in mice. J Infect Dis. 2010 Apr 15;201(8):1270-1; author reply 1271-2. doi: 10.1086/651279. PubMed PMID: 20225958.

  91. Pei Y, Tarun AS, Vaughan AM, Herman RW, Soliman JM, Erickson-Wayman A, Kappe SH. Plasmodium pyruvate dehydrogenase activity is only essential for the parasite's progression from liver infection to blood infection. Mol Microbiol. 2010 Feb;75(4):957-71. doi: 10.1111/j.1365-2958.2009.07034.x. PubMed PMID: 20487290.

  92. Jacobs-Lorena VY, Mikolajczak SA, Labaied M, Vaughan AM, Kappe SH. A dispensable Plasmodium locus for stable transgene expression. Mol Biochem Parasitol. 2010 May;171(1):40-4. doi: 10.1016/j.molbiopara.2009.12.009. Epub 2010 Jan 4. PubMed PMID: 20045029; PubMed Central PMCID: PMC2839042.

  93. Vaughan AM, Wang R, Kappe SH. Genetically engineered, attenuated whole-cell vaccine approaches for malaria. Hum Vaccin. 2010 Jan;6(1):107-13. doi: 10.4161/hv.6.1.9654. Epub 2010 Jan 29. Review. PubMed PMID: 19838068; PubMed Central PMCID: PMC3641786.

  94. Aly AS, Vaughan AM, Kappe SH. Malaria parasite development in the mosquito and infection of the mammalian host. Annu Rev Microbiol. 2009;63:195-221. doi: 10.1146/annurev.micro.091208.073403. Review. PubMed PMID: 19575563; PubMed Central PMCID: PMC2841446.

  95. Tarun AS, Vaughan AM, Kappe SH. Redefining the role of de novo fatty acid synthesis in Plasmodium parasites. Trends Parasitol. 2009 Dec;25(12):545-50. doi: 10.1016/j.pt.2009.09.002. Epub 2009 Oct 12. PubMed PMID: 19819758.

  96. Tang C, Liu Y, Kessler PS, Vaughan AM, Oram JF. The macrophage cholesterol exporter ABCA1 functions as an anti-inflammatory receptor. J Biol Chem. 2009 Nov 20;284(47):32336-43. doi: 10.1074/jbc.M109.047472. Epub 2009 Sep 25. PubMed PMID: 19783654; PubMed Central PMCID: PMC2781648.

  97. Vaughan AM, O'Neill MT, Tarun AS, Camargo N, Phuong TM, Aly AS, Cowman AF, Kappe SH. Type II fatty acid synthesis is essential only for malaria parasite late liver stage development. Cell Microbiol. 2009 Mar;11(3):506-20. doi: 10.1111/j.1462-5822.2008.01270.x. Epub 2008 Dec 3. PubMed PMID: 19068099; PubMed Central PMCID: PMC2688669.

  98. Sankaranarayanan S, Oram JF, Asztalos BF, Vaughan AM, Lund-Katz S, Adorni MP, Phillips MC, Rothblat GH. Effects of acceptor composition and mechanism of ABCG1-mediated cellular free cholesterol efflux. J Lipid Res. 2009 Feb;50(2):275-84. doi: 10.1194/jlr.M800362-JLR200. Epub 2008 Sep 30. PubMed PMID: 18827283; PubMed Central PMCID: PMC2636919.

  99. Vaughan AM, Aly AS, Kappe SH. Malaria parasite pre-erythrocytic stage infection: gliding and hiding. Cell Host Microbe. 2008 Sep 11;4(3):209-18. doi: 10.1016/j.chom.2008.08.010. Review. PubMed PMID: 18779047; PubMed Central PMCID: PMC2610487.

    select

  100. Vaughan AM, Tang C, Oram JF. ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation. J Lipid Res. 2009 Feb;50(2):285-92. doi: 10.1194/jlr.M800366-JLR200. Epub 2008 Sep 5. PubMed PMID: 18776170; PubMed Central PMCID: PMC2636916.

  101. Vaughan A, Chiu SY, Ramasamy G, Li L, Gardner MJ, Tarun AS, Kappe SH, Peng X. Assessment and improvement of the Plasmodium yoelii yoelii genome annotation through comparative analysis. Bioinformatics. 2008 Jul 1;24(13):i383-9. doi: 10.1093/bioinformatics/btn140. PubMed PMID: 18586738; PubMed Central PMCID: PMC2718618.

  102. Mikolajczak SA, Aly AS, Dumpit RF, Vaughan AM, Kappe SH. An efficient strategy for gene targeting and phenotypic assessment in the Plasmodium yoelii rodent malaria model. Mol Biochem Parasitol. 2008 Apr;158(2):213-6. doi: 10.1016/j.molbiopara.2007.12.006. Epub 2007 Dec 15. PubMed PMID: 18242728.

  103. Oram JF, Vaughan AM. ATP-Binding cassette cholesterol transporters and cardiovascular disease. Circ Res. 2006 Nov 10;99(10):1031-43. doi: 10.1161/01.RES.0000250171.54048.5c. Review. PubMed PMID: 17095732.

  104. Landry YD, Denis M, Nandi S, Bell S, Vaughan AM, Zha X. ATP-binding cassette transporter A1 expression disrupts raft membrane microdomains through its ATPase-related functions. J Biol Chem. 2006 Nov 24;281(47):36091-101. doi: 10.1074/jbc.M602247200. Epub 2006 Sep 19. PubMed PMID: 16984907.

  105. Vaughan AM, Oram JF. ABCA1 and ABCG1 or ABCG4 act sequentially to remove cellular cholesterol and generate cholesterol-rich HDL. J Lipid Res. 2006 Nov;47(11):2433-43. doi: 10.1194/jlr.M600218-JLR200. Epub 2006 Aug 10. PubMed PMID: 16902247.

  106. Amenya DA, Koekemoer LL, Vaughan A, Morgan JC, Brooke BD, Hunt RH, Ranson H, Hemingway J, Coetzee M. Isolation and sequence analysis of P450 genes from a pyrethroid resistant colony of the major malaria vector Anopheles funestus. DNA Seq. 2005 Dec;16(6):437-45. doi: 10.1080/10425170500356727. PubMed PMID: 16287623.

  107. Tang C, Vaughan AM, Anantharamaiah GM, Oram JF. Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1. J Lipid Res. 2006 Jan;47(1):107-14. doi: 10.1194/jlr.M500240-JLR200. Epub 2005 Oct 6. PubMed PMID: 16210729.

  108. Vaughan AM, Oram JF. ABCG1 redistributes cell cholesterol to domains removable by high density lipoprotein but not by lipid-depleted apolipoproteins. J Biol Chem. 2005 Aug 26;280(34):30150-7. doi: 10.1074/jbc.M505368200. Epub 2005 Jun 30. PubMed PMID: 15994327.

  109. David JP, Strode C, Vontas J, Nikou D, Vaughan A, Pignatelli PM, Louis C, Hemingway J, Ranson H. The Anopheles gambiae detoxification chip: a highly specific microarray to study metabolic-based insecticide resistance in malaria vectors. Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4080-4. doi: 10.1073/pnas.0409348102. Epub 2005 Mar 7. PubMed PMID: 15753317; PubMed Central PMCID: PMC554807.

  110. Ranson H, Paton MG, Jensen B, McCarroll L, Vaughan A, Hogan JR, Hemingway J, Collins FH. Genetic mapping of genes conferring permethrin resistance in the malaria vector, Anopheles gambiae. Insect Mol Biol. 2004 Aug;13(4):379-86. doi: 10.1111/j.0962-1075.2004.00495.x. PubMed PMID: 15271210.

    select

  111. Tang C, Vaughan AM, Oram JF. Janus kinase 2 modulates the apolipoprotein interactions with ABCA1 required for removing cellular cholesterol. J Biol Chem. 2004 Feb 27;279(9):7622-8. doi: 10.1074/jbc.M312571200. Epub 2003 Dec 9. PubMed PMID: 14668333.

  112. Oram JF, Wolfbauer G, Vaughan AM, Tang C, Albers JJ. Phospholipid transfer protein interacts with and stabilizes ATP-binding cassette transporter A1 and enhances cholesterol efflux from cells. J Biol Chem. 2003 Dec 26;278(52):52379-85. doi: 10.1074/jbc.M310695200. Epub 2003 Oct 14. PubMed PMID: 14559902.

  113. Vaughan AM, Oram JF. ABCA1 redistributes membrane cholesterol independent of apolipoprotein interactions. J Lipid Res. 2003 Jul;44(7):1373-80. doi: 10.1194/jlr.M300078-JLR200. Epub 2003 Apr 16. PubMed PMID: 12700343.

  114. Oram JF, Vaughan AM, Stocker R. ATP-binding cassette transporter A1 mediates cellular secretion of alpha-tocopherol. J Biol Chem. 2001 Oct 26;276(43):39898-902. doi: 10.1074/jbc.M106984200. Epub 2001 Aug 23. PubMed PMID: 11546785.

  115. Oram JF, Vaughan AM. ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Curr Opin Lipidol. 2000 Jun;11(3):253-60. doi: 10.1097/00041433-200006000-00005. Review. PubMed PMID: 10882340.

  116. Hemingway J, Coleman M, Paton M, McCarroll L, Vaughan A, Desilva D. Aldehyde oxidase is coamplified with the World's most common Culex mosquito insecticide resistance-associated esterases. Insect Mol Biol. 2000 Feb;9(1):93-9. doi: 10.1046/j.1365-2583.2000.00160.x. PubMed PMID: 10672076.

  117. Lawn RM, Wade DP, Garvin MR, Wang X, Schwartz K, Porter JG, Seilhamer JJ, Vaughan AM, Oram JF. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest. 1999 Oct;104(8):R25-31. doi: 10.1172/JCI8119. PubMed PMID: 10525055; PubMed Central PMCID: PMC481052.

  118. Karunaratne SH, Vaughan A, Paton MG, Hemingway J. Amplification of a serine esterase gene is involved in insecticide resistance in Sri Lankan Culex tritaeniorhynchus. Insect Mol Biol. 1998 Nov;7(4):307-15. doi: 10.1046/j.1365-2583.1998.740307.x. PubMed PMID: 9723868.

  119. ffrench-Constant RH, Pittendrigh B, Vaughan A, Anthony N. Why are there so few resistance-associated mutations in insecticide target genes?. Philos Trans R Soc Lond B Biol Sci. 1998 Oct 29;353(1376):1685-93. doi: 10.1098/rstb.1998.0319. Review. PubMed PMID: 10021768; PubMed Central PMCID: PMC1692388.

  120. Vaughan A, Chadee DD, French-Constant R. Biochemical monitoring of organophosphorus and carbamate insecticide resistance in Aedes aegypti mosquitoes from Trinidad. Med Vet Entomol. 1998 Jul;12(3):318-21. doi: 10.1046/j.1365-2915.1998.00111.x. PubMed PMID: 9737606.

  121. DeSilva D, Hemingway J, Ranson H, Vaughan A. Resistance to insecticides in insect vectors of disease: est alpha 3, a novel amplified esterase associated with amplified est beta 1 from insecticide resistant strains of the mosquito Culex quinquesfasciatus. Exp Parasitol. 1997 Nov;87(3):253-9. doi: 10.1006/expr.1997.4245. PubMed PMID: 9371091.

  122. Vaughan A, Hawkes N, Hemingway J. Co-amplification explains linkage disequilibrium of two mosquito esterase genes in insecticide-resistant Culex quinquefasciatus. Biochem J. 1997 Jul 15;325 ( Pt 2)(Pt 2):359-65. doi: 10.1042/bj3250359. PubMed PMID: 9230114; PubMed Central PMCID: PMC1218568.

  123. Ranson H, Cornel AJ, Fournier D, Vaughan A, Collins FH, Hemingway J. Cloning and localization of a glutathione S-transferase class I gene from Anopheles gambiae. J Biol Chem. 1997 Feb 28;272(9):5464-8. doi: 10.1074/jbc.272.9.5464. PubMed PMID: 9038148.

  124. Karunaratne SH, Hemingway J, Jayawardena KG, Dassanayaka V, Vaughan A. Kinetic and molecular differences in the amplified and non-amplified esterases from insecticide-resistant and susceptible Culex quinquefasciatus mosquitoes. J Biol Chem. 1995 Dec 29;270(52):31124-8. doi: 10.1074/jbc.270.52.31124. PubMed PMID: 8537374.

  125. Vaughan A, Hemingway J. Mosquito carboxylesterase Est alpha 2(1) (A2). Cloning and sequence of the full-length cDNA for a major insecticide resistance gene worldwide in the mosquito Culex quinquefasciatus. J Biol Chem. 1995 Jul 14;270(28):17044-9. doi: 10.1074/jbc.270.28.17044. PubMed PMID: 7622525.

  126. Vaughan A, Rodriguez M, Hemingway J. The independent gene amplification of electrophoretically indistinguishable B esterases from the insecticide-resistant mosquito Culex quinquefasciatus. Biochem J. 1995 Jan 15;305 ( Pt 2)(Pt 2):651-8. doi: 10.1042/bj3050651. PubMed PMID: 7530448; PubMed Central PMCID: PMC1136411.

  127. Vaughan A, Ketterman AJ, Hemingway J. Comparisons of nucleic acid sequences of esterases from resistant and susceptible strains of Culex quinquefasciatus. Biochem Soc Trans. 1993 Nov;21(4):481S. doi: 10.1042/bst021481s. PubMed PMID: 8132048.

  128. Sumner IG, Vaughan A, Eisenthal R, Pickersgill RW, Owen AJ, Goodenough PW. Kinetic analysis of papaya proteinase omega. Biochim Biophys Acta. 1993 Aug 7;1164(3):243-51. doi: 10.1016/0167-4838(93)90255-p. PubMed PMID: 8393709.

  129. Vize PD, Vaughan A, Krieg P. Expression of the N-myc proto-oncogene during the early development of Xenopus laevis. Development. 1990 Nov;110(3):885-96. doi: 10.1242/dev.110.3.885. PubMed PMID: 2088727.